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Today study aims to investigate the prognostic role of methodical inflammatory and nutritional indexes in extensive-stage small-cell lung cancer (ES-SCLC) treated with first-line chemotherapy and atezolizumab. Prospective mate population involving 53 clients were determined from NCT03041311 trial. The following peripheral blood-derived inflammatory and nutritional indexes, consisting of neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), prognostic nutrition index (PNI), advanced lung cancer inflammation index (ALI), and lung immune prognostic index (LIPI) were examined.

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23, 2. 73, 2. 57, 119. 23, 48, 533. 28 and 2. 32, respectively. With a mean follow-up of 17. 1 months, the 1-year OS and PFS were 56% and 8%, respectively. Multivariate analysis revealed that PLR was the only independent prognostic factors for OS amongst ES-SCLC clients treated with chemotherapy and atezolizumab (HR 4.
00-21. 46, p = 0. 05). K-M analysis showed that the OS and PFS for patients with high PLR (> 119. 23) were significantly poorer than these with low PLR (119. 23) (p = 0. 0004 for OS and p = 0. 014 for PFS). In Full Article , diagnosis of clients with high PLR was also significantly poorer than these with low PLR in regards to OS (p = 0.
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028). Pre-treatment PLR might work as an important independent prognostic element for ES-SCLC who get chemotherapy and immune checkpoint inhibitors. Further, prospective research studies are still required to validate our findings. Atezolizumab; Platelet lymphocyte ratio; Diagnosis; Small-cell lung cancer.
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